イリスンは,αVインテグリン受容体を通して,骨と脂肪に作用する
Hyeonwoo Kim1, Christiane D Wrann2, Mark Jedrychowski1
1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA.
Cell
|December 15, 2018
まとめ
運動ホルモンのイリシンはαVインテグリンに結合し,その受容体として作用する. この発見は,アイリシンが
科学分野:
- 運動生理学
- 分子生物学
- 骨の生物学
背景:
- 筋肉に分泌されるホルモンであるアイリスンは 運動の効果を様々な組織に媒介します
- イリシンの骨格への作用とその受容体は,ほとんど不明である.
- イリシンの骨格の役割を理解することは 骨の健康と運動科学にとって不可欠です
研究 の 目的:
- イリシンの受容体を特定する
- 骨格の改造と骨の喪失における イリシンの役割を明らかにするために
- イリシンの骨格作用の 基礎にある分子メカニズムを理解するために
主な方法:
- イリシンとインテグリンの相互作用を特定するための生体学的研究.
- 骨細胞と脂肪細胞におけるαVインテグリンの化学阻害
- 卵巣切除による骨の喪失モデルにおけるFNDC5 (イリシン) の遺伝子切除.
主要な成果:
- アイリスンはαVインテグリン,特にαV/β5インテグリンと結合する.
- αVインテグリン阻害は,骨細胞と脂肪細胞におけるアイリシンシグナル伝達を阻害する.
- アイリスインは骨細胞生存とスクレロスティンの生成を高め,FNDC5の切除は卵巣切除による骨の損失を防ぐ.
結論:
- αVインテグリンはアイリシン受容体として機能する.
- アイリスンは骨格の再構築と骨の喪失を防ぐのに重要な役割を果たします.
- イリシン受容体を特定することで 運動が骨の健康に 与える効果を理解できます
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