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男性の乳児向け攻撃の多感性論理
Yoh Isogai1, Zheng Wu2, Michael I Love3
1Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA; Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London W1T 4JG, UK.
Cell
|December 15, 2018
まとめ
ヴァーメロナザル受容体が関与する特定の物理的および化学的なシグナルにより,ヴァーメロナザルマウスは幼虫を攻撃します. 男性マウスの複雑な感覚処理を強調しています.
科学分野:
- 神経科学
- 動物 の 行動
- 化学エコロジー
背景:
- 新生児は大人から親の世話を受けますが 処女の雄は攻撃的です
- 子犬に対する雄の攻撃には 吐口器官の機能が必要です
- 男性の攻撃を誘発する 幼児の特定のシグナルは 未確認のままです
研究 の 目的:
- 処女マウスの攻撃的な反応を誘発する 特定の乳児のシグナルを特定するために
- この攻撃的な行動に関与する 嘔吐鼻受容体とフェロモン化合物を 解明するために
主な方法:
- 再構成された子犬のシグナルを使って 行動パラダイムを開発した.
- 乳幼児の信号で活性化された 吐口鼻受容体
- 遺伝子を消去して 反応者の関与を確認した
- フェロモンの化合物を分離するために生化学的分離を用いる.
主要な成果:
- 乳児の形状の特徴と唾液の化学信号は 男性の攻撃性を強く引き出します
- Vmn2r65とVmn2r88が攻撃に特に関与している7つのヴォメロナザル受容体が特定されました.
- 2つのフェロモン化合物,下腺タンパク質Cとヘモグロビンが分離されました.
- 特定されたシグナルや受容体は 子犬に限ったものではなかった.
結論:
- 赤ん坊による攻撃性には 処女男性における 身体的特徴や化学的信号の認識が含まれます
- この攻撃の背後にある感覚メカニズムは 子犬特有のものではありません.
- この研究は,雄のマウスの攻撃における 複雑な化学感覚処理を明らかにした.
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