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Updated: Feb 1, 2026

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites
09:31

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites

Published on: March 22, 2016

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HMCESは,単一鎖DNAのアバシックサイトをシールドすることで,ゲノム整合性を維持する

Kareem N Mohni1, Sarah R Wessel1, Runxiang Zhao1

  • 1Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Cell
|December 18, 2018
PubMed
まとめ

研究者らは,単一鎖DNAの基礎部位のための新しいセンサーであるESC特異の5-hydroxymethylcytosine (5hmC) 結合を発見した. この古代のタンパク質は 自殺酵素として作用し 変異を防止し ゲノムの完全性を保ちます

キーワード:
5-ヒドロキシメチルサイトシンDNA 修復DNA複製DNAとタンパク質のクロスリンクHMCES についてPCNA についてREV1 についてSRAP について複製ストレストランスレションDNA合成

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