タンパク質 の よう に 折りたたむ 複雑な 分子 は,自発 的 に 生じ ます
Bin Liu1, Charalampos G Pappas1, Ennio Zangrando2
1Centre for Systems Chemistry , Stratingh Institute , Nijenborgh 4, 9747 AG Groningen , The Netherlands.
Journal of the American Chemical Society
|December 19, 2018
まとめ
複雑な折りたたまれた分子は 自律的に組み立てられます この研究は,単純なサブユニットから複雑な構造を形成し,新しい分子構造の道を開く自己合成マクロサイクリック折り畳み器を明らかにしています.
科学分野:
- 合成化学
- 生物化学
- 生命の研究の起源
背景:
- 大分子折りたたみで タンパク質の性質は様々です
- 以前は 複雑な折りたたみ分子には 自然な進化や 広範な設計と合成が必要でした
- 複雑な分子構造の自律的形成は以前は実証されなかった.
研究 の 目的:
- 単純な先駆体から複合的折りたたまれた分子の自律的かつ選択的な出現を証明する.
- 新しく複雑な構造を持つ自己合成マクロサイクルの折りたたみ物質を特定する.
- 複雑な合成分子を作るための実行可能なアプローチとしてダイナミックな組み合わせ化学を確立する.
主な方法:
- ダイナミック・コンビネトリアル・ケミストリー・アプローチ
- 相互変換する分子の混合物から 1段階の合成
- シングルクリスタルX線結晶学と核磁共振 (NMR) スペクトロスコーピーを用いた特徴付け.
主要な成果:
- 15個の同一のペプチド核基子単位から構成された自己合成マクロサイクリック・フォルダマーの識別.
- 複合構造の折りたたみによる合成で95%の収量を達成した.
- 互換性のない相互作用の ネットワークによって安定した 二次と三次構造を明らかにした
結論:
- ダイナミック・コンビネトリアル・ケミストリーは,現在の設計能力を超える折り畳みモチーフを持つ合成分子の作成を可能にします.
- 複雑な折りたたまれた分子の自律的形成は,初期のアビオゲネシスにおける潜在的な役割を示唆している.
- この研究は様々な科学分野での応用の可能性のある 複雑な分子構造の設計に新たな道を開きます
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