アニオン-π相互作用に向けて,前もって設計された二重マクロサイクル受容体とダイアニオンによる自己組み立て
De-Hui Tuo1,2, Wei Liu1, Xue-Yuan Wang1,2
1Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry , Chinese Academy of Sciences , Beijing 100190 , China.
Journal of the American Chemical Society
|December 19, 2018
まとめ
研究者は,アニオン-π相互作用を可能にする新しいバイマクロサイクル分子を作成しました. これらの分子は自己組織化して オーダーされた構造を形成し 穴の方向性を通して 粒子の形成と形状のコントロールを 示している.
科学分野:
- 超分子化学
- 材料科学
- 有機化学
背景:
- アニオン-π相互作用は自己組織化に不可欠ですが,中性受容体では達成することは困難です.
- 超分子構造の組み立てと形態を制御することは,材料科学の重要な目標です.
研究 の 目的:
- アニオンπ駆動の自己組み立てのための新しいビソクサカリックス[2]アレン[2]トリアジンビルディングブロックの設計と合成.
- 分子認識と自己組み立て行動に対するリンク器の剛性と分岐角の影響を調査する.
- オーダーされた集合体の形成を調査し,これらのビスマクロサイクル成分を使用してその形態論を制御する.
主な方法:
- ビソクサカリックス[2]アレン[2]トリアジンの合成
- 分子構造と穴の方向を決定するX線結晶学.
- ホスト・ゲストの相互作用を評価するための溶液相結合試験 (例えば,1H NMR タイトレーション)
- 溶液中の集積を研究するための光譜技術 (DOSY,ESI-MS) と分散方法 (DLS)
- 顕微鏡技術 (SEM,TEM,cryo-TEM,AFM) で自己組み立て構造を視覚化しています.
主要な成果:
- 硬いリンクは,ビソクサカリックス[2]アレン[2]トリアジンにおけるマクロサイクリック空洞の方向性を成功裏に制御した.
- ホスト分子は選択的塩化物結合を示し,180°および120°の分岐性同位体に対する二重複合化を示した.
- アニオン-πとナフタレン-1,5-ジスルフォナートとの相互作用は,長距離自己組み立てと一貫した粒子の形成を誘導した.
- マクロサイクルの空洞の方向性は,結果として生じる粒子の形状に大きく影響した.
結論:
- ビソカリックス[2]アレン[2]トリアジンは,アニオンπ誘発の自己組み立てのための効果的な構成要素である.
- 分子設計,特にリンク器の硬さと分岐は,結合特性と自己組み立て結果を決定する.
- アニオン-π相互作用は,宿主集合体を橋渡しし,オーダーされた超分子構造の形成を指揮する上で重要な役割を果たします.
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