熱的ストレスにより,骨髄性状態を経由して,糖分解性ベージュ脂肪の形成が誘発される
Yong Chen1,2,3,4, Kenji Ikeda1,2,3, Takeshi Yoneshiro1,2,3
1UCSF Diabetes Center, San Francisco, CA, USA.
Nature
|December 21, 2018
まとめ
研究者達は新しいタイプのベージュ脂肪を発見しました 典型的なシグナル伝達経路なしに 寒さへの適応に不可欠なものです この発見は細胞の可塑性と エネルギー調節のための新しいメカニズムを明らかにしています
科学分野:
- 細胞の可塑性と適応
- 代謝の調節
- 熱生成
背景:
- 筋肉の繊維の種類や 脂肪細胞の発達などに 影響を及ぼします
- 生理学的刺激と発達的な可塑性を結びつける分子機構は完全に理解されていません.
- 寒さへの適応は,ベージュ色脂肪細胞の生体生成のためのβ-アドレナergicシグナル伝達を含みます.
研究 の 目的:
- 慢性的な寒さへの適応に関与する 新種のベージュアディポサイトを調査する
- この独特のベージュ色の脂肪のサブタイプを制御する分子メカニズムを明らかにする.
- エネルギー・ホメオスタシスと生存における その役割を理解するためです
主な方法:
- 新しいベージュの脂肪細胞サブタイプの特徴.
- 熱ストレスに対する遺伝子調節の分析
- GA結合タンパク質αを含む主要な調節タンパク質の特定
- 発達の起源とシグナル伝達経路の調査
主要な成果:
- 特徴的なベージュの脂肪細胞群を特定し, glycolytic beige fat と呼ばれ, β- アドレナジックシグナル伝達なしに機能している.
- この糖分分解ベージュの脂肪は 強化されたグルコース酸化を示します
- GA結合タンパク質αは,ミオゲン介質によるその分化における重要な調節因子として特定された.
- 熱生成のための非正規の適応経路を示した.
結論:
- 慢性的な寒さに適応する ユニークなメカニズムです
- この経路は,熱的ストレスによって誘発された原始細胞の可塑性を強調します.
- エネルギーの安定と生存に不可欠な 新しい細胞成分を明らかにします
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