生涯運動訓練用量の心房動脈結合への影響
Michinari Hieda1, Erin Howden1,2, Shigeki Shibata1,3
1Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, and University of Texas Southwestern Medical Center (M.H., E.H., S.S., N.F., PS.B., J.L.H., T.T., S.S., Q.F., R.Z., B.D.L.).
Circulation
|December 21, 2018
まとめ
終身運動は高齢者の心臓機能を保ちます 効率的な心房動脈結合と 老化とともに動的スターリング機構を維持するために 週に4〜5回の運動セッションを行うことが最適である.
科学分野:
- 心臓病科
- 運動 生理学
- ゲロントロジー
背景:
- 動的スターリングメカニズムは 心室と動脈の結合に不可欠で 年齢とともに衰退します
- 高度な訓練を受けたマスター・アスリートはこのメカニズムを維持しますが,必要な生涯の運動量は不明です.
- この関係を理解することは 高齢者の心血管機能の保全の鍵です
研究 の 目的:
- 健康な高齢者における生涯にわたる運動とダイナミックなスターリングメカニズムとの間にある用量依存関係を調査する.
- 老化とともに心房と動脈の結合を維持するために必要な最適な運動量を決定する.
主な方法:
- 102人の高齢者は,週間の運動頻度 (過去25年) に基づいて,座っている,気軽な,コミットされた,競争力のあるマスター・アスリートグループに分類されました.
- 動的スターリングメカニズムは,肺動脈圧のビートバイビートの変化と脳卒中の体積指数間の移転機能の獲得を使用して評価されました.
- ピーク酸素吸収 (Vo2) と左心室の硬さも測定された.
主要な成果:
- 移転機能の獲得は,座っている人と比較して,コミット (4〜5セッション/週) と競争力のある (6〜7セッション/週) 運動者において有意に増加しました.
- 酸素吸収のピークが高く 左下室の硬直度が上昇した.
- 座っている成人は肺動脈の圧力の変動が大きかったが,競争力のある運動者は脳卒中の体積指数の変動が大きかった.
結論:
- 健康な高齢者において,心室動脈結合の漸進的な,用量依存の改善が観察される.
- 生涯にわたる運動,特に週に4〜5回の運動は,心房と動脈の結合と老化とともに起こる ダイナミックなスターリングメカニズムの維持に最適であるようです.
さらに関連する動画
関連する概念動画
Impact of Groups on Groups
246
Social psychologists analyze how groups influence one another, shaping social structures and interactions through both cooperation and competition. These dynamics manifest in various ways, ranging from economic partnerships to intergroup conflicts that shape societal structures and perceptions.Cooperation and Competition in Intergroup RelationsIntergroup relationships vary across contexts, sometimes fostering cooperation and mutual benefit while at other times leading to conflict and...
246
Exercise Stress Test
1.3K
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
1.3K
Spin–Spin Coupling: Two-Bond Coupling (Geminal Coupling)
1.7K
Two NMR-active nuclei bonded to a central atom can be involved in geminal or two-bond coupling. Geminal coupling is commonly seen between diastereotopic protons in chiral molecules and unsymmetrical alkenes, among others.
The central atom need not be NMR-active because its electrons are affected by the electron polarization of the spin-active atoms. However, spin information is transmitted less effectively than in one-bond coupling, and 2J values are usually weaker than 1J values. The energy of...
The central atom need not be NMR-active because its electrons are affected by the electron polarization of the spin-active atoms. However, spin information is transmitted less effectively than in one-bond coupling, and 2J values are usually weaker than 1J values. The energy of...
1.7K
Spin–Spin Coupling: Three-Bond Coupling (Vicinal Coupling)
1.5K
Vicinal or three-bond coupling is commonly observed between protons attached to adjacent carbons. Here, nuclear spin information is primarily transferred via electron spin interactions between adjacent C‑H bond orbitals. This generally favors the antiparallel arrangement of spins, so 3J values are usually positive.
The extent of coupling depends on the C‑C bond length, the two H‑C‑C angles, any electron-withdrawing substituents, and the dihedral angle between the involved orbitals. The...
The extent of coupling depends on the C‑C bond length, the two H‑C‑C angles, any electron-withdrawing substituents, and the dihedral angle between the involved orbitals. The...
1.5K
Dose Size and Dosing Frequency: Determination Methods
298
Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
298
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
236
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
236


