新生児の心臓再生: 総合的な文献レビュー

Nicholas T Lam¹, Hesham A Sadek^1,2

¹Department of Internal Medicine, Division of Cardiology (N.T.L and H.A.S.).

Circulation

|December 21, 2018

まとめ

哺乳類の新生児の心臓は大人の心臓とは違って傷を負った後に再生できますこのレビューでは,新生児の心臓再生に関する研究を分析し,回復に影響を与える要因を強調し,重要な研究課題を特定しています.

科学分野:

心血管医学
発達生物学
再生医療

背景:

成人哺乳類の心臓は損傷後の機能回復能力が限られています
哺乳類の新生児の心臓は様々な傷害の後再生の可能性を示します
新生児の心臓再生を理解することは心血管疾患の治療法の開発に不可欠です

研究の目的:

新生児の哺乳類の心臓再生に関する既存の研究を総合的に分析する.
重要な発見,課題,未解決の疑問を特定する.
心臓の修復に関する将来の研究に基盤を提供するためです

主な方法:

キーワード"新生児""心臓""再生"を使って体系的なPubMed検索を行いました
新生児の心臓再生に関する研究を引用した研究を含む.
手術モデル,傷害のタイミング,評価方法に関する出版物の検討

主要な成果:

新生児のマウスのアピカル切除と冠動脈結合は,心筋細胞増殖を介して強固な再生を促進します.
新生児マウスの心臓の再生は不完全でした
傷の大きさと手術方法は回復に大きく影響します

結論:

新生児の心臓再生は,アピカル切除と冠動脈連結後,生後2日以内に一貫して観察されています.
凍結傷は同様の再生反応を引き出さない.
再生は心筋細胞の増殖によって引き起こされ,外部の影響や損傷の特徴を含む複数の要因に影響されます.

キーワード:

心筋細胞の増殖心臓の再生哺乳類の新生児

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