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Updated: Jan 31, 2026

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
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CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

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結合した単細胞CRISPRスクリーニングとエピジェノミックプロファイリングは,因果的な遺伝子規制ネットワークを明らかにする

Adam J Rubin1, Kevin R Parker2, Ansuman T Satpathy3

  • 1Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Cell
|December 25, 2018
PubMed
まとめ

Perturb-ATACは,CRISPR遺伝子編集とクロマチンのアクセシビリティプロフィールを組み合わせて,遺伝子調節をマッピングする新しい単細胞法です. このアプローチは,転写因子がヒトの細胞のアイデンティティと発達をどのように制御するかを明らかにします.

キーワード:
ATAC-seqCRISPRについてクロマチンのアクセシビリティエピゲノミクスプールされたスクリーン単細胞ゲノム

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