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Updated: Jan 31, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
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Published on: August 3, 2018

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LMO7は成長因子βシグナル伝達と線維症のネガティブフィードバックレギュレータである

Yi Xie1,2, Allison C Ostriker1,2, Yu Jin1,2

  • 1Departments of Medicine (Cardiovascular Medicine) (Y.X., A.C.O., Y.J., K.A.M., J.H.), Yale University, New Haven, CT.

Circulation
|December 28, 2018
PubMed
まとめ

LIMドメイン7 (LMO7) だけが,変形成長因子β (TGF-β) のシグナリングを否定的に調節することによって,血管繊維症を制限する. LMO7の喪失はTGF-β反応を強め,血管損傷後のネオインティマル形成と線維症を促進する.

キーワード:
細胞外マトリックス繊維症滑らかな筋肉転写因子変化する成長因子

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