関連する実験動画

Updated: Jan 31, 2026

Establishment and Validation of a Rat Model of Pulmonary Arterial Hypertension Associated with Pulmonary Fibrosis
07:11

Establishment and Validation of a Rat Model of Pulmonary Arterial Hypertension Associated with Pulmonary Fibrosis

Published on: May 23, 2025

935

Bmpr2 ミュータントラットは肺動脈高血圧の肺と心臓の特徴を発症する

Aurélie Hautefort1,2,3,4, Pedro Mendes-Ferreira5,6, Jessica Sabourin7

  • 1Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France (A.H., G.M., C.R.-M., M.R., M.L., F.L., D.M., B.G., M.H., F.A., F.P.).

Circulation
|December 28, 2018
PubMed
まとめ

Bmpr2遺伝子の欠損を患った突然変異のラットは,肺動脈高血圧 (PAH) と右心室機能不全を発症し,ヒトの病気を模倣する. この新しいラットモデルは,PAHの病原性と潜在的な治療目標の洞察を提供します.

キーワード:
骨形態遺伝タンパク質受容体II型心血管疾患肺高血圧インタールイキン-6モデル 動物筋細胞,心臓

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