機能不全および炎症抑制性Tリンパ球は,性心筋不全における不良心筋再構成に不可欠である
Shyam S Bansal1,2, Mohamed Ameen Ismahil1, Mehak Goel1
1Division of Cardiovascular Disease and Comprehensive Cardiovascular Center, University of Alabama at Birmingham (S.S.B., M.A.I., M.G., G.Z., G.R., T.H., S.D.P.).
Circulation
|December 28, 2018
まとめ
機能不全のTリンパ球 (Tregs) は炎症と心不全の進行を促進する. Treg機能の回復は,不全性心筋病および心不全の治療戦略を提供することができる.
科学分野:
- 免疫学
- 心臓病科
- 分子生物学
背景:
- 心不全 (HF) は持続的な炎症を伴うもので,免疫抑制の喪失を示唆する.
- 主要な免疫抑制体であるTリンパ球 (Tregs) のHFにおける役割は,現在不明である.
研究 の 目的:
- Tregsが不全性心筋病とHFで機能不全しているという仮説を検証する.
- 機能不全のTregsが免疫活性化と左心房 (LV) の改造に寄与するかどうかを判断する.
主な方法:
- 心筋梗塞を誘発するマウスモデルを用いた.
- エコーカーディオグラフィー, ヒストロジー, 分子分析で評価した.
- フロー・サイトメトリー,免疫ステーリング,インビトロ測定を用いてTregプロファイルと機能を検査した.
主要な成果:
- HFマウスでは,Tregsが拡張し,炎症促進機能,免疫調節能力の低下,および抗血管新生/プロフィブロティック特性を促進した.
- 選択的Treg除去は,LVの改造と機能不全を逆転させ,炎症を軽減し,新血管化を強化した.
- Treg機能障害はTNFR1依存の血管新生抑制と循環中の血管新生細胞動員と関連していた.
結論:
- 慢性発血性HFの病原性において,プロ炎症性および抗血管性Tregsは重要な役割を果たしています.
- 正常なTreg機能の回復は,HF免疫調節のための潜在的な治療方法を示しています.
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