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Updated: Jan 31, 2026

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella
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ライアノジン受容体グリケーションは老朽化した心臓のミトコンドリア損傷を助長する

Marisol Ruiz-Meana1,2, Marta Minguet1, Diana Bou-Teen1

  • 1Vall d'Hebron Institut de Recerca, University Hospital Vall d'Hebron-Universitat Autònoma, Barcelona, Spain (M.R-M., M.M., D.B-T., E.M-C., J.C., A.I., R.R-L., D.G-D.).

Circulation
|December 28, 2018
PubMed
まとめ

特にRyR2のタンパク質グリケーションが増加し,カルシウム漏れとミトコンドリア機能障害を引き起こします. このグリケーションは老化中の心筋細胞のエネルギー供給を阻害し,心不全を引き起こします.

キーワード:
年老化カルシウムミトコンドリアサルコプラズマネットワーク

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