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Updated: Jan 31, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

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グルコース感受性ミオカイン/カルディオカイン MG53は,全身インスリン反応と代謝性ホメオスタシスを調節する

Hong-Kun Wu1, Yan Zhang1, Chun-Mei Cao1

  • 1State Key Laboratory of Membrane Biology, Institute of Molecular Medicine (H.-K.W., Y.Z., C.-M.C., X.H., M.F., Y.Y., L.J., G.C., P.J., S.Z., R.S., W.P., F.L., J.G., L.T., Y.H., D.S., Z.Z., F.L., R.-P.X.).

Circulation
|December 28, 2018
PubMed
まとめ

Mitsugumin 53 (MG53) は,高血糖に対する反応として,筋肉と心臓によって分泌され,インスリン抵抗性を引き起こします. MG53を中和化することで,2型糖尿病 (T2DM) の治療が可能になる.

キーワード:
MG53 について糖尿病 2 型グルコース代謝障害インスリン抵抗性メタボリックシンドローム肥満インスリン受容体

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Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test06:59

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Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
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Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
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