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Measurements of Physiological Stress Responses in C. Elegans
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休息時の生理学的指数の生理学的および臨床的評価
Joo Myung Lee1, Ki Hong Choi1, Jonghanne Park2,3,4
1Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea (J.M.L., K.H.C., Y.B.S., J.-Y.H.).
Circulation
|December 28, 2018
まとめ
静止圧導指数である静止全サイクル比 (RFR) と腹圧比 (dPR) は,瞬時無波比 (iFR) と高い一致を示し,冠動脈疾患における結果を予測する. これらの方法は患者の治療戦略を導くことができます.
科学分野:
- 心臓病科
- 介入心臓科
- 生理学
背景:
- 静止圧による新しい指数は,静止全サイクル比率 (RFR) と腹圧比率 (dPR) を含め,冠動脈狭窄の機能的意義を評価するために出現しています.
- 以前の研究は,冠動脈疾患の評価のための瞬時無波比 (iFR) と分流準備量 (FFR) に焦点を当てていた.
- RFRとdPRの臨床的有用性と確立されたインデックスとの一致性については,さらなる調査が必要である.
研究 の 目的:
- RFRとdPRが iFRとFFRと合意したことを調査する.
- アナトミック・ヘモダイナミック・ステノシスの重さを判断するためのRFRとdPRの感度を評価する.
- RFRとdPRとiFRの予後効果を比較して,不良心血管疾患を予測する.
主な方法:
- RFRとdPRは,435人の患者からの1024人の血管の静止圧追跡から計算された.
- iFRとFFRとの一致性と相関性が分析された.
- 115人の患者で13N-アンモニア・ポジトロン放出トモグラフィーを用いて診断性能を評価した.
- 予測値は,延期された864隻の2年間の船舶指向の複合結果との関連を分析することによって評価されました.
主要な成果:
- RFRとdPRは高い相関性とiFRとの一致性を示した (R=0. 979,C-インデックス=0. 987RFR;R=0. 985,C-インデックス=0. 993dPR),FFRとの相関性を超えた.
- 心筋不全の予測におけるiFR,RFR,dPRの診断性能は比較可能であった.
- すべての休息時の生理学指標 (iFR,RFR,dPR) は,2年間の血管指向の有害な複合アウトカムリスクの減少と有意に関連していました.
結論:
- RFRとdPRを含む静止圧力指数は,iFRと非常に一致しています.
- これらの指数は狭窄症の重さに敏感で,心筋不全の診断性能も同様です.
- RFRとdPRは,iFRとともに,冠動脈疾患の治療戦略を導くための貴重な侵襲的ツールとして機能します.
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