短鎖脂肪酸プロピオネートは高血圧性心血管損傷から保護する
Hendrik Bartolomaeus1,2,3,4,5, András Balogh1,2,3,4,5, Mina Yakoub6
1Experimental and Clinical Research Center, a Cooperation of Charité-Universitätsmedizin Berlin and Max Delbruck Center for Molecular Medicine, Germany (H.B., A.B., L.M., D.T., S.W., E.G.A., N.H., K.K., J.F., M.G., R.D., S.K.F., D.N.M., N.W.).
Circulation
|December 28, 2018
まとめ
プロピオネートのような短鎖脂肪酸 (SCFA) は,T細胞の反応を調節することによって高血圧と心血管損傷から守ることができます. SCFAの生成を増加させる食事の変更は,心血管疾患の非薬物予防戦略を提供することができます.
科学分野:
- 心血管科学
- 免疫学
- 微生物群の研究
背景:
- 動脈高血圧とその後遺症はT細胞媒介の炎症を伴う.
- 実験的な抗炎症療法は高血圧の末端臓器の損傷を緩和する有望な結果を示しています
- 腸内微生物から派生した短鎖脂肪酸 (SCFA) は免疫ホメオスタシスと心血管の健康に影響を与えます.
研究 の 目的:
- マウスモデルにおける高血圧性心損傷と動脈硬化に対するSCFAプロピオネットの効果を調査する.
- プロピオネットの心臓保護効果の根底にある免疫調節メカニズムを明らかにする.
主な方法:
- 野生型のNMRIとアポリポプロテインEノックアウトマウスに飲用水でプロピオネートまたはコントロールを投与した.
- 2つのマウスモデルでアンジオテンシンII輸液による高血圧.
- ヒストロジー,エコーカルジオグラフィ,フローサイトメトリー,免疫光を用いて心臓損傷,動脈硬化,免疫細胞のプロフィールを評価した.
主要な成果:
- プロピオネートは心筋縮,線維症,血管機能障害,高血圧を弱めた.
- 心律不全への感受性の低下と大動脈硬化病変の領域の減少
- 特定のT細胞の集団と局所的な心臓免疫細胞の浸透を減らすことで全身の炎症を緩和した.
- 心臓保護効果は,T細胞の調節に依存していた.
結論:
- SCFAはプロピオネートと同様に,心血管の健康に有益な免疫調節性を持っています.
- ライフスタイルの変化によってSCFAの産生を増やすことは,高血圧性心血管疾患の非薬理学的予防策として機能する.
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