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Updated: Jan 31, 2026

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
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DNA インターケレーションは,フェナントリプラチンの効率的なDNA標的型共性結合を促進します

Ali A Almaqwashi1, Wen Zhou2,3, M Nabuan Naufer4

  • 1Physics Department , King Abdulaziz University , Rabigh 21911 , Saudi Arabia.

Journal of the American Chemical Society
|January 3, 2019
PubMed
まとめ

抗癌薬であるフェナントリプラチンは,2段階のインターケレーションとコヴァレンント結合のプロセスを通してDNAを迅速に結合します. このメカニズムは同位体とは異なり,効果的なDNAターゲティングを可能にします.

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