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Updated: Jan 31, 2026

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Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
Published on: May 28, 2007
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イエメンにおける2016~2017年のコレラ流行に関するゲノム分析
François-Xavier Weill1, Daryl Domman2,3, Elisabeth Njamkepo4
1Institut Pasteur, Unité des Bactéries Pathogènes Entériques, Paris, France. francois-xavier.weill@pasteur.fr.
Nature
|January 4, 2019
まとめ
イエメンの最大のコレラ流行は,第7のパンデミックV. cholerae O1 El Tor (7PET) 系統の単一の南アジア系から発生した. イエメン
科学分野:
- 微生物学
- ゲノミクス
- 流行病学について
背景:
- イエメンでは史上最大のコレラ流行が起こっており,2016年9月から110万人以上の症例と2,300人の死亡が報告されています.
- 流行は2つの異なる波で発生し,第2波は2017年4月に始まり,疑わしい症例が100万人を超えました.
研究 の 目的:
- イエメンの疫病から分離されたビブリオ・コレラ菌の遺伝子関係,病原性,および抗菌剤耐性決定因子を調査する.
- イエメンの疫病単離体を,第7のパンデミックV.コレラ O1エル・トル (7PET) 系統のグローバルな文脈に置く.
主な方法:
- イエメンと周辺地域から116種のVibrio choleraeの全ゲノム配列解析
- これらの配列の系統遺伝分析は,第7のパンデミックV.コレラO1およびO139バイオタイプエル・トル単離体1087のグローバルコレクションとともに行われました.
主要な成果:
- イエメンの疫病単離体は7PET系統の1つの亜系統,特にV. choleraeのOgawa血型に属しています.
- この亜系は南アジアで始まり 東アフリカで発生し その後イエメンに広がった.
- イエメンの単離物は,一般的に使用されるコレラ治療とポリミキシンBに敏感です.
結論:
- イエメンのコレラ流行は 7PET系統の特定の南アジア亜系統と関連しています
- ゲノムによる監視は,パンデミックコレラの世界的な拡散と進化を理解するために不可欠です.
- 主要な抗生物質に対するイエメン単離体の感受性は,有効な治療選択肢が利用可能であることを示唆しています.
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