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Open and closed-loop control systems01:17

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オプトジェネティック・周辺神経調節のための無線閉環システム

Aaron D Mickle1,2, Sang Min Won3, Kyung Nim Noh3

  • 1Washington University Pain Center and Department of Anesthesiology, Washington University, St Louis, MO, USA.

Nature
|January 4, 2019
PubMed
まとめ
この要約は機械生成です。

バイオエレクトロニクス医学は 神経刺激を用いて 膀の過剰活動などの症状を治療します 臓器機能を改善し 副作用を軽減する 精密な閉環光生性神経調節のための 新しいインプラントを導入しています

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科学分野:

  • バイオエレクトロニック医学
  • 神経調節
  • バイオテクノロジー

背景:

  • バイオエレクトロニクス医学は,外周神経系の刺激を介して病状を治療することを目的としています.
  • 現在の電気刺激方法は特異性がなく,不快感や怪我を引き起こす可能性があります.
  • 既存の治療法は 断続的な症状と 特定の臓器をターゲットにしています

研究 の 目的:

  • 現在の神経調節技術の限界を克服するために ミニチュア化された生物光電子インプラントを開発します
  • 精密で臓器特異的な閉ループ神経調節を可能にし,治療結果を改善します.
  • 病的な臓器の行動を リアルタイムでモニタリングし 自動で修正する

主な方法:

  • マイクロスケールの無機発光ダイオードで オプシンを活性化する 新しい光学刺激インターフェースを使用した.
  • 臓器機能を継続的に監視するための柔らかい,高精度の生体物理センサーシステム (例えば,膀ストレンスメーター) が組み込まれています.
  • 制御モジュールを実装し,データ分析を調整し,閉ループの光遺伝神経調節を行いました.

主要な成果:

  • ネズミモデルでの膀機能のリアルタイム測定をソフトストレージメーターで実証した.
  • 病理的な膀の行動を特定するためのデータアルゴリズムを開発した.
  • 閉経神経調節で 膀の機能を正常化させました

結論:

  • 完全光学神経調節システムは 慢性的な安定性と高い特異性を提供します
  • この技術は断続的な症状の治療と 臓器特異性の改善のための 潜在的な解決策を提供します
  • 開発されたシステムは,オプトジェネティクスによる臓器機能の正確な,リアルタイム,閉路制御を可能にします.