プロテイン 水分化 水 は 不 利 な 乱れ に 容易 に 陥る
Journal of the American Chemical Society
|January 8, 2019
まとめ
タンパク質の水分化水は タンパク質の機能とフェーズ行動の鍵です シミュレーションにより タンパク質は これらの水分を 湿潤の移行点に配置し 干渉に敏感にします
科学分野:
- バイオ物理学
- コンピュータ生物学
- タンパク質科学
背景:
- タンパク質の機能は 周囲の水分子との相互作用と密接に関連しています
- タンパク質の水分化を理解することは,タンパク質のフェーズ行動と生物学的活動を理解するために不可欠です.
研究 の 目的:
- 異なる性質のタンパク質と,その水分化の水の相互作用を特徴づける.
- タンパク質の水分化殻の湿潤感を調べる
- タンパク質と水の相互作用を分類するための枠組みを開発する.
主な方法:
- タンパク質と水の相互作用を研究するために 分子シミュレーションを用いた.
- 補水殻の振る舞いを分析するために 強化されたサンプリング技術を使用した.
- 大きさや形や化学成分や機能が異なる タンパク質を研究した.
主要な成果:
- タンパク質は水分化の水分を水分化表面に似せて 脱水移行の端に配置する.
- 湿気を誘発するのに必要なエネルギーは 異なるタンパク質に一致します
- 濡れやすさは主に水分殻の幅に依存する.
結論:
- タンパク質の水分化殻は 微妙なバランスを保ち 混乱に敏感です
- タンパク質の水分化層の脱水を 支配する普遍的な原理があります
- タンパク質の表面領域を,その水相互作用強度に基づいて分類する方法を確立した.
関連する概念動画
Aldehydes and Ketones with Water: Hydrate Formation
4.8K
An oxygen-based nucleophile, like water, can undergo addition reactions with aldehydes and ketones. The reaction leads to the formation of hydrates, also referred to as 1,1-diols or geminal diols.
The formation of hydrates is a reversible reaction. Hydrate formation is influenced by steric and electronic factors accompanying the alkyl substituents on the carbonyl group: The rate of hydrate formation increases with a decrease in the number of alkyl groups attached to the carbonyl carbon. Hence,...
The formation of hydrates is a reversible reaction. Hydrate formation is influenced by steric and electronic factors accompanying the alkyl substituents on the carbonyl group: The rate of hydrate formation increases with a decrease in the number of alkyl groups attached to the carbonyl carbon. Hence,...
4.8K
Hydration of Cement
915
Hydration of cement is a chemical reaction between cement particles and water. This process occurs primarily through two mechanisms: through-solution and topochemical. In the through-solution process, anhydrous compounds dissolve into their constituents, hydrates form in the solution, and then precipitate from the supersaturated solution. The topochemical process involves solid-state reactions at the cement particle surface. The through-solution process dominates the topochemical process at the...
915
Aqueous Solutions and Heats of Hydration
17.9K
Water and other polar molecules are attracted to ions. The electrostatic attraction between an ion and a molecule with a dipole is called an ion-dipole attraction. These attractions play an important role in the dissolution of ionic compounds in water.
When ionic compounds dissolve in water, the ions in the solid separate and disperse uniformly throughout the solution because water molecules surround and solvate the ions, reducing the strong electrostatic forces between them. This process...
When ionic compounds dissolve in water, the ions in the solid separate and disperse uniformly throughout the solution because water molecules surround and solvate the ions, reducing the strong electrostatic forces between them. This process...
17.9K
Magnetic Susceptibility and Permeability
2.4K
In linear magnetic materials, like paramagnets and diamagnets, magnetization is proportional to the magnetic field intensity. The constant of proportionality, a dimensionless number, is called magnetic susceptibility. The value of the susceptibility depends on the type of material.
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
2.4K
Strength and Heat of Hydration
687
The hydration of cement is an exothermic reaction in which heat is generated as cement hydrates. This heat of hydration is critical to cement's strength development. The rate at which this heat is generated affects the temperature rise, with a majority of the heat being released early in the hydration process, half within the first three days, and about 75% within the first week.
The heat of hydration for each cement compound is significant; for instance, tricalcium aluminate (C3A) and...
The heat of hydration for each cement compound is significant; for instance, tricalcium aluminate (C3A) and...
687
States of Water
56.8K
Water exists in any one of the three classical states: solid (ice), liquid (water), and gas (steam or water vapor). The state of water depends on i) the intermolecular forces that draw molecules together and ii) the kinetic energy that leads to movements that pull them apart.
Water freezes when the intermolecular forces are greater than the kinetic energy. Unlike most other substances, water is less dense in its solid state than in its liquid state. This is because each water molecule can form...
Water freezes when the intermolecular forces are greater than the kinetic energy. Unlike most other substances, water is less dense in its solid state than in its liquid state. This is because each water molecule can form...
56.8K


