カルコゲンとハロゲン結合と直接比較したプニクトゲン結合によるアニオン輸送
Lucia M Lee1, Maria Tsemperouli1, Amalia I Poblador-Bahamonde1
1School of Chemistry and Biochemistry, NCCR Chemical Biology , University of Geneva , CH-1211 Geneva , Switzerland.
Journal of the American Chemical Society
|January 9, 2019
まとめ
カルコゲン結合は,プニクトゲン結合とハロゲン結合に比べて,超膜アニオン輸送が優れている. ビス (perfluorophenyl) テルランは高効率のキャリアとして作用し,高い選択性を示し,膜破壊を避けます.
科学分野:
- 超分子化学
- 膜輸送
- ハロゲン結合
背景:
- 脂質二層の間のアニオン輸送は生物学的プロセスにとって極めて重要です.
- プニクトゲン,カルコゲン,およびハロゲン結合は,分子認識および輸送の可能性のある非共性相互作用である.
- 選択的で効率的なアニオンキャリアの開発は,超分子化学の重要な課題です.
研究 の 目的:
- プニクトゲン結合化合物によって媒介されるトランスメブランアニオン輸送を導入し,調査する.
- プニクトゲン結合媒体の効能と特性を,カルコゲン結合媒介とハロゲン結合媒介と比較する.
- アニオン輸送効率と選択性を支配する構造的および電子的要因を解明する.
主な方法:
- プニクトゲン結合 (アンチモニー中心) とカルコゲン結合 (テルリウム中心) 化合物の合成と特徴付け.
- 超膜アニオン電流と単一チャネル特性を測定するための電気生理学的研究.
- 膜の破損を評価するための染料漏れ測定
- 異なるアニオンとカチオンを用いた選択性研究
主要な成果:
- プニクトゲン結合化合物 (トリス (perfluorophenyl) ステバン) は"強すぎる"アニオン結合を示し,膜破壊と不規則な電流を引き起こした.
- カルコゲン結合化合物 (bis ((perfluorophenyl) テルラン) は,ナノモラー活性と高い選択性 (例えば,P ((Cl/Na) = 10.4) を有する効率的なアニオン輸送を証明した.
- ハロゲン結合化合物 (ヨウ素を中心に) は,有意に活動性が低下した (3 度より低い).
- ピニクトゲン結合媒体は,膜障害により選択性が低下した.
結論:
- カルコゲン結合は,特にビス (perfluorophenyl) テルランは,トランスメブランアニオン輸送に非常に有効である.
- カルコゲン結合システムの2次元構造,方向性,防水性,およびアニオン-π相互作用は,その優れた性能に貢献する.
- パニクトゲン結合とハロゲン結合は,カルコゲン結合と比べて効率的で破壊性のないアニオン輸送に適していません.
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