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Updated: Jan 30, 2026

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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アミロイド前駆体タンパク質のヒトのγ-分泌酵素による認識

Rui Zhou1, Guanghui Yang1, Xuefei Guo1

  • 1Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Science (New York, N.Y.)
|January 12, 2019
PubMed
まとめ

研究者は,ヒトのガンマ分泌酵素 (γ-分泌酵素) がアミロイド前駆体タンパク質 (APP) 断片に結合する原子構造を決定し,アルツハイマー病 (AD) と潜在的な治療標的に関連する重要な相互作用を明らかにした.

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