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Updated: Jan 30, 2026

Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury
08:27

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活性化PMNエクソソーム:マトリックス破壊と肺疾患を引き起こす病原体

Kristopher R Genschmer1, Derek W Russell1, Charitharth Lal2

  • 1Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, The University of Alabama at Birmingham, Birmingham, AL 35294, USA; Lung Health Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA; Program in Protease and Matrix Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Cell
|January 12, 2019
PubMed
まとめ

新型中性粒子を産生したエクソソームは中性粒子の弾性酶 (NE) を携えており,細胞外マトリックスを分解することで慢性閉塞性肺疾患 (COPD) と支支氣管肺不形成症 (BPD) を引き起こします. これらのエクソソームは阻害剤に耐性を持ち,疾患のフェノタイプを伝達します.

キーワード:
BPD についてCOPD についてELA-2 についてエラスタゼエクソソーム細胞外マトリックス細胞外膀炎症肺の病気マイクロ粒子中性子

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