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Updated: Jan 30, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
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Published on: September 28, 2012

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バクテリア から 人間 へ の タンパク質 ネットワーク は,内生 的 な DNA 損傷 の 起源 を 明らかに し て い ます

Jun Xia1, Li-Ya Chiu2, Ralf B Nehring3

  • 1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA.

Cell
|January 12, 2019
PubMed
まとめ

科学者はDNAダメージアップタンパク質 (DDPs) を特定し,過剰に生成されるとDNAに損傷を与えます. これらのタンパク質は,ヒトのがん発症と不良の予後に関連しており,変異性におけるその役割を強調しています.

キーワード:
DNA 損傷反応DNAの二重鎖の断裂DNMT1 についてエシェリキア・コライ癌について進化についてゲノムの不安定性人間の細胞微生物がんモデル複製フォークの逆転

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