まとめ
腸内ラクトフェリン補給は,非常に早産の乳児における遅発の感染症を減少させなかった. この大規模な試験は,この脆弱な集団における感染を予防するために,牛乳フェリンは日常的に推奨されないことを示唆しています.
科学分野:
- 新生児医学
- 感染症
- 臨床試験
背景:
- 病院での感染は 極めて早産児に重大なリスクをもたらします
- 以前の研究では,ラクトフェリンサプリメントが感染を予防することが示唆されました.
- この試験は,より大きなコホートでこれらの発見を検証することを目的とした.
研究 の 目的:
- 腸内牛乳フェリンは,非常に早産の乳児における遅発の感染症を軽減するかどうかを判断する.
- 臨床実践のガイドラインに 確固たる証拠を提供すること.
主な方法:
- イギリスの37の病院で 2203人の早産児を対象とした大規模な ランダム化プラセボ対照試験です
- 乳児は月経後34週まで毎日牛乳酸フェリンまたはサクラロースを投与された.
- 主なアウトカムは微生物学的に確認されたまたは臨床的に疑われる遅発の感染でした.
主要な成果:
- ラクトフェリン群 (29%) と対照群 (31%) の間では,遅発の感染率に有意な差はなかった.
- 感染に対する調整されたリスク比率は0. 95 (95%CI 0. 86- 1. 04; p=0. 233) であった.
- 重篤な有害事象は類似しており,2件はラクトフェリンに関連している可能性がある.
結論:
- 腸経牛乳フェリンの補給は,非常に早産の乳児の遅発感染のリスクを効果的に軽減しません.
- 現状の証拠は,この集団における感染予防のためのラクトフェリンの日常的な使用を支持しません.
- 特定のサブグループや代替的介入を探るにはさらなる研究が必要かもしれません.
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