活性バイオポリマーネットワークを合成ヒドロゲルで模倣する
Marcos Fernández-Castaño Romera1, Robert Göstl, Huda Shaikh
1SupraPolix BV , Horsten 1 , 5612 AX , Eindhoven , The Netherlands.
Journal of the American Chemical Society
|January 15, 2019
まとめ
合成ポリマーは加熱すると 劇的に硬くなり 生物学的組織を模倣します 液体からゲルへの物質の移行は 医学的な応用のための新しい生体材料を可能にします
科学分野:
- バイオマテリアル科学
- ポリマー化学
- バイオ物理学
背景:
- 細胞は周囲のマトリックスを固め,分子モーターは細胞骨格の性質を変化させるなど,生体システムは生体力学的なプロセスのために内部ストレスを生み出します.
- 合成材料のストレス生成を理解することは 生物学的機能を模倣する鍵です
研究 の 目的:
- 熱反応性ポリマーで交互に結合された合成繊維のマトリックスで内部ストレス生成とマクロスコーピック硬化を示す.
- 調整可能な機械的性質を持つ合成材料の設計の可能性を調査する.
主な方法:
- 合成半柔軟ポリマーマトリックスと熱反応性ポリ ((N-イソプロピラクリラミド) (PNIPAM) を化学的に交結する.
- PNIPAMでコイルから球体への移行を誘導する.
- 切断ストレス下でのモジュールの変化とパワーの法則を測定するレオロギー分析.
主要な成果:
- 交結した繊維状のマトリクスは,PNIPAMのコイルから球体への移行時に,マクロスケールの硬化反応を示した.
- PNIPAMの崩壊によって生じた力は 液体物質を瞬く間に固いゲルに変えました
- 硬化されたネットワークは,プレストレスの高い生物学的ネットワークに匹敵する力法則のレオロギー指数でシール誘発の硬化を示した.
結論:
- 熱反応性ポリマーによって引き起こされる内部ストレスは,合成繊維材料の高速で大規模な硬化のためのメカニズムを提供します.
- 動力法則のレオロジーを含む観察された機械的性質は,コラーゲンやアクトミオシンネットワークのような生物学的組織と似ています.
- このアプローチは 細胞と組織のメカニズムを模倣して 体温で液体から固体に 移行する高度な合成ヒドロゲルの 開発の経路を提供します
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