脊椎動物の後腸の形成を促すのは,マクロスコープによる力による分子制御である
Nandan L Nerurkar1,2,3, ChangHee Lee4, L Mahadevan5,6,7,8
1Department of Genetics, Harvard Medical School, Boston, MA, USA. nln2113@columbia.edu.
Nature
|January 18, 2019
まとめ
早期の胚性腸管形成,特に後腸の発達は,集団的な細胞の動きと収縮力グラデントによって引き起こされます. 線維細胞成長因子のシグナル伝達によって影響されるこのグラデントは,適切な臓器形成のために組織の伸びと細胞の採用を導く.
科学分野:
- 発達生物学
- 細胞生物学
- バイオ物理学
背景:
- 胚の腸管は呼吸道と胃腸の基礎を形成する.
- 早期の内皮の発達と後の臓器形成は研究されているが,腸管の形成はあまり理解されていない.
- 既存のモデルでは,特に前腸では,移動ポータル (AIPとCIP) を介して腸管の形成を記述しています.
研究 の 目的:
- 初期の胚性腸管形態変異における力の分子制御を調査する.
- 後腸形成の特徴的なメカニズムを明らかにする.
- 後腸の発達を促す信号伝達経路と物理的力を特定する.
主な方法:
- 鶏の胚の体内画像
- 生物物理分析と数学モデリング
- 分子と胚の技術
主要な成果:
- CIPの移動ではなく,集団的な細胞移動によって形成されます.
- 収縮力のグラデーションは 後部腸の延長を促します
- 線維細胞成長因子 (FGF) 信号グラデーションは,力グラデーションを確立します.
- 陽性フィードバックループが 細胞を後腸に誘導します
結論:
- 後腸の発達には前腸の形成とは異なるメカニズムが伴う.
- 組織規模の力は脊椎動物の形態変異に不可欠であり,発達信号にたどり着くことができます.
- FGFのシグナル伝達と細胞の収縮は 腸管の伸びを誘導する相互作用です
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