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CRIF1-CDK2インターフェース阻害剤:細胞の放射線感受性の調節のための前例のない戦略

Qian Ran1, Yang Xiang1, Preyesh Stephen2

  • 1Department of Blood Transfusion, Irradiation Biology Laboratory , Xinqiao Hospital , Chongqing , 400037 , China.

Journal of the American Chemical Society
|January 18, 2019
PubMed
まとめ

CRIF1- CDK2の相互作用を標的とする新薬候補は,骨肉腫細胞の増殖を選択的に抑制し,放射線感受性を高めます. このアプローチは,がん治療のサイクリン依存キナーゼ (CDK) 標的化における選択性の問題を克服します.

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