痛みの不快さをコードする 桃体神経集合体
Gregory Corder1,2,3,4, Biafra Ahanonu5,6,7, Benjamin F Grewe5,7
1Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Science (New York, N.Y.)
|January 19, 2019
まとめ
研究者達は 痛みを伴う 否定的な感情をコード化する 特定の神経回路を発見しました この回路をターゲットにすることで 他の感覚や感情の反応に影響を及ぼさずに 痛みの行動を減らすことができます
科学分野:
- 神経科学
- 痛みに関する研究
- 感情 神経科学
背景:
- 痛みの否定的な感情的経験の 背後にある脳のメカニズムは 完全に理解されていません
- 痛みの知覚と感情状態を結びつける神経回路の調査は 痛みの知覚を理解するために重要です
研究 の 目的:
- 痛みの嫌悪感を 引き起こしている神経の集合を 特定するためです
- 神経病痛を含む急性および慢性疼痛状態におけるこの神経集合体の役割を調査する.
主な方法:
- 自由に行動するマウスで in vivo カルシウム画像を用いた.
- 特定の神経集合体の機能を研究するために神経活動操作技術を採用した.
- 有害な刺激に対する行動反応,不安,報酬,触覚性アロディニアの評価
主要な成果:
- 痛みの負の感情をコードする ベース・ラテラル・アミグダラの 独特なニューラル・アンサンブルを特定しました
- このアンサンブルを静止すると 痛みに関連した感情的動機付けの行動が減ったが 感覚の検出や不安には影響しなかった.
- 無害な刺激が神経疾患の疼痛モデルで この組み合わせを活性化させ アロディニアを引き起こすことが観察されました
結論:
- 特定された桃体神経群は,急性および慢性疼痛の両方の負の感情的要素にとって重要です.
- これらの発見は 痛みの嫌悪性の神経基礎と 痛みの障害の潜在的な治療目標の洞察を提供します
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