関連する実験動画

Updated: Jan 30, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

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ヒトセマフォリン3変異はメラノコルチン回路の発達とエネルギーバランスを結びつける

Agatha A van der Klaauw1, Sophie Croizier2, Edson Mendes de Oliveira1

  • 1University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

Cell
|January 22, 2019
PubMed
まとめ

セマフォリン3 (SEMA3) のシグナル伝達は,体重を調節する脳の回路の発達に不可欠です. SEMA3経路の遺伝子の遺伝子変異は重度の肥満と関連しており,エネルギーホメオスタシスに影響します.

キーワード:
アグRPニューロピリンプレキシンポムクセマフォリン3sヒポタラムス肥満

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