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Nav1.7の構造的基礎 ゲーティング修正スパイダー毒素による阻害

Hui Xu1, Tianbo Li2, Alexis Rohou1

  • 1Department of Structural Biology, Genentech, South San Francisco, CA 94080, USA.

Cell
|January 22, 2019
PubMed
まとめ

この研究では,Protoxin-II (ProTx2) がNav1. 7チャネルに結合し,このタランチュラ毒素がナトリウムチャネル (Nav) 機能をブロックする方法を明らかにしました. これは,新しいNavチャネルブロックの設計のための構造的基礎を提供します.

キーワード:
ナビ1.7ゲーティングモデルゲーティング改変剤毒素阻害剤 システィンノットプロトキシンIIボルトゲートナトリウムチャネル

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