半島の構造は,非同期的な分化と形態変異を調整して,臓の小島を生成する
Nadav Sharon1, Raghav Chawla2, Jonas Mueller3
1Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Cell
|January 22, 2019
まとめ
研究者らは 臓の小島形状と内分泌細胞の分化が 直接関連していることを発見しました この発見は既存の信念に異議を唱え,糖尿病治療のための in vitro 島生成を進める可能性があります.
科学分野:
- 発達生物学
- 内分泌学
- 幹細胞生物学
背景:
- ランゲルハンスの臓の小島は,グルコースホメオスタシスに不可欠です.
- インスリンを産生するベータ細胞の喪失は糖尿病につながる.小島移植は治癒の可能性がある.
- 島の発達を理解することは,in vitro島生産の鍵です.
研究 の 目的:
- 臓の小島形成と形態形成の過程を明らかにする.
- 内分泌の分化と小島構造の関係を調査する.
- 機能的な小島を生成する方法を in vitro で探求する.
主な方法:
- 単細胞mRNA配列解析を用いて,臓の小島群の発達を分析した.
- 祖先細胞の移動と分化ダイナミクスの観察
- ヒト胚幹細胞の分化における半島状構造の誘導
主要な成果:
- ドグマに反して,小島形状と内分泌の分化が直接関係しています.
- "半島"と呼ばれる凝固した芽状の構造を形成する.
- アルファ細胞が外層を形成し ベータ細胞が続いて コア・マントルの構造を確立します
結論:
- 内分泌の分化と小島形態変異の間には直接的な空間時間的な関係がある.
- 半島の形成は成熟した小島建築の発展に先行する.
- 半島のような構造の成功誘導は,in vitroの全島生成の経路を提供します.
関連する概念動画
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
2.4K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
Insulin and C-peptide are...
2.4K
Morphogenesis
30.4K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
30.4K
Coordination Number and Geometry
19.0K
For transition metal complexes, the coordination number determines the geometry around the central metal ion. Table 1 compares coordination numbers to molecular geometry. The most common structures of the complexes in coordination compounds are octahedral, tetrahedral, and square planar.
19.0K
Coordination Compounds and Nomenclature
26.7K
In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
26.7K
Lattice Centering and Coordination Number
11.5K
The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
Types of Unit Cells
Imagine taking a large number of identical...
11.5K
Structural Isomerism
21.7K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
21.7K


