ヒトの抗体レパートリーにおける例外的な多様性にもかかわらず,共通点
Bryan Briney1,2,3,4,5, Anne Inderbitzin6,7, Collin Joyce6,8,9,10
1Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. briney@scripps.edu.
Nature
|January 22, 2019
まとめ
人間の抗体レパートリーは 非常に多様で 何兆もの独特の抗体があります この研究では,約30億の抗体配列を分析し,適応性免疫系における個々のユニーク性と共有された抗体特性を明らかにしました.
科学分野:
- 免疫学
- ゲノミクス
- バイオ情報学
背景:
- 人間の適応性免疫システムは,様々な抗原を認識するための膨大な抗体レパートリーを生成します.
- 抗体レパートリーの膨大な多様性は,歴史的に包括的な研究を制限しています.
- 現在の研究は,アクセシビリティのため,循環するB細胞に焦点を当てています.
研究 の 目的:
- 人類の抗体レパートリーを 前例のない規模で分析する
- 循環するB細胞集団の多様性と特徴を調査する.
- 抗体レパートリーの遺伝子研究のための大規模なデータセットを提供すること.
主な方法:
- 10人の人の抗体重鎖配列を分析した
- 循環するB細胞の集団に集中する.
- 適応性免疫受容体の遺伝子の大規模な配列化とデータ分析.
主要な成果:
- この研究は,これまでで最大の適応性免疫受容体配列を提示しています.
- 抗体レパートリーは個人に大きく異なっていることが判明しました.
- 全般的に共有される抗体クローン型のサブ集団が特定されました.
- ヒトの抗体レパートリーの例外的な全体的な多様性が確認された.
結論:
- ヒトの抗体レパートリーは 驚くべき多様性と 個々の特異性を表しています
- この発見は,抗体レパートリーの基礎遺伝学を理解するための基本的なデータセットを提供します.
- 共同でユニークな抗体クローンタイプの影響をさらに調査することができます.
さらに関連する動画
関連する概念動画
Exceptions to the Octet Rule
37.5K
Many covalent molecules have central atoms that do not have eight electrons in their Lewis structures. These molecules fall into three categories:
37.5K
Common Ion Effect
46.6K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
46.6K
Diversity of Archaea I
625
Archaea, a domain of single-celled microorganisms, are classified into five major phyla based on genetic and biochemical characteristics: Euryarchaeota, Crenarchaeota, Thaumarchaeota, Korarchaeota, and Nanoarchaeota. Among these, the phylum Euryarchaeota is notable for its remarkable diversity in morphology, metabolism, and ecological adaptations.Morphological and Metabolic DiversityMembers of Euryarchaeota exhibit a variety of cellular shapes, including rods and cocci. Their metabolic pathways...
625
Cell Diversity
5.0K
The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular...
Multicellular...
5.0K
Diversity of Archaea II
518
Archaea, one of the three domains of life, exhibit remarkable diversity and adaptability, thriving in both extreme and moderate environments. Historically, most identified archaea have been classified into two major phyla: Euryarchaeota and Crenarchaeota. However, recent molecular studies have expanded this classification to include three additional phyla: Thaumarchaeota, Nanoarchaeota, and Korarchaeota, each exhibiting unique characteristics and ecological roles.Thaumarchaeota: Mesophiles...
518
Diversity of Protists I
1.2K
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
1.2K


