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Updated: Jan 30, 2026

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
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リガンドとレドックス・パートナーの結合は,シトクロームP450カム (CYP101A1) で新しい適合状態を生成する

Alec H Follmer1, Sarvind Tripathi2, Thomas L Poulos1

  • 1Departments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry , University of California , Irvine , California 92697-3900 , United States.

Journal of the American Chemical Society
|January 24, 2019
PubMed
まとめ

サイトクロームP450は開いた状態と閉じた状態の間でシフトする. 新しい構造は,シアン化物結合が大きな形状変化を誘導し,P450酵素触媒にとって重要な新しい活性部位アクセスチャネルを開くことを明らかにします.

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