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メタボトロピックグルタミン酸受容体の活性化に関する構造的洞察

Antoine Koehl1, Hongli Hu1,2, Dan Feng3

  • 1Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|January 25, 2019
PubMed
まとめ

メタボトロピクグルタミン酸受容体5の活性化には,形状の変化が含まれます. アゴニストがベヌス・フライトラップドメインに結合すると,7トランスメブランドメインの構造的な再配置が始まり,シグナル伝達が始まります.

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