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関連する概念動画

The Synapse02:47

The Synapse

133.1K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
133.1K
Hormonal Regulation01:40

Hormonal Regulation

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Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
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GTPases and their Regulation02:14

GTPases and their Regulation

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Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
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Electrical Synapses01:28

Electrical Synapses

10.6K
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
10.6K
Chemical Synapses01:26

Chemical Synapses

11.5K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
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Chemical Synapses01:26

Chemical Synapses

4.6K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
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Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation
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Published on: October 6, 2011

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異なる分子プログラムは,皮質抑制回路におけるシナプス特異性を調節する.

Emilia Favuzzi1,2,3, Rubén Deogracias1,2,3, André Marques-Smith1,2

  • 1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.

Science (New York, N.Y.)
|January 26, 2019
PubMed
まとめ
この要約は機械生成です。

特定の分子プログラムがマウスの脳内で GABAergic 内ニューロンの接続を導く. これらの細胞特有のプログラムが シナプス標的を決定し 阻害回路の形成と脳の機能を形作ります

さらに関連する動画

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
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In Vivo Two-photon Imaging Of Experience-dependent Molecular Changes In Cortical Neurons
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関連する実験動画

Last Updated: Jan 30, 2026

Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation
09:50

Mapping Inhibitory Neuronal Circuits by Laser Scanning Photostimulation

Published on: October 6, 2011

17.8K
Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

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In Vivo Two-photon Imaging Of Experience-dependent Molecular Changes In Cortical Neurons
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In Vivo Two-photon Imaging Of Experience-dependent Molecular Changes In Cortical Neurons

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科学分野:

  • 神経科学
  • 分子生物学
  • 発達生物学

背景:

  • 神経の接続は 認知機能に不可欠な 機能的な脳ネットワークを形成します
  • 哺乳類の脳皮質のGABAergicインターニューロンは,時間動力学と情報処理に不可欠な多様な接続パターンを示します.
  • インターニューロン固有の接続性を駆動する分子メカニズムは,ほとんど不明である.

研究 の 目的:

  • マウスにおける皮質抑制回路の発達中の異なるインターニューロンクラスの転写ダイナミクスを調査する.
  • インターニューロン特異のシナプスターゲティングの分子基礎を解明する.

主な方法:

  • 異なるインターニューロンサブタイプにおける転写ダイナミクスの分析.
  • 産後初期におけるシナプス分子発現パターンの調査.

主要な成果:

  • ピラミッド細胞 (デンドライト,ソマ,またはアクソン初期セグメント) の神経内シナプス形成は,シナプス分子のサブタイプ特異的な発現によって決定される.
  • 異なる分子プログラムは,回路形成中に異なるインターニューロンクラスで活性化します.

結論:

  • 初期の発達期に確立された細胞特有の分子プログラムは,皮質内ニューロンの正確な接続パターンの根底にある.
  • これらのプログラムを理解することは 阻害回路の組み立てと機能を解読する鍵です