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異なる分子プログラムは,皮質抑制回路におけるシナプス特異性を調節する
Emilia Favuzzi1,2,3, Rubén Deogracias1,2,3, André Marques-Smith1,2
1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.
Science (New York, N.Y.)
|January 26, 2019
まとめ
特定の分子プログラムがマウスの脳内で GABAergic 内ニューロンの接続を導く. これらの細胞特有のプログラムが シナプス標的を決定し 阻害回路の形成と脳の機能を形作ります
科学分野:
- 神経科学
- 分子生物学
- 発達生物学
背景:
- 神経の接続は 認知機能に不可欠な 機能的な脳ネットワークを形成します
- 哺乳類の脳皮質のGABAergicインターニューロンは,時間動力学と情報処理に不可欠な多様な接続パターンを示します.
- インターニューロン固有の接続性を駆動する分子メカニズムは,ほとんど不明である.
研究 の 目的:
- マウスにおける皮質抑制回路の発達中の異なるインターニューロンクラスの転写ダイナミクスを調査する.
- インターニューロン特異のシナプスターゲティングの分子基礎を解明する.
主な方法:
- 異なるインターニューロンサブタイプにおける転写ダイナミクスの分析.
- 産後初期におけるシナプス分子発現パターンの調査.
主要な成果:
- ピラミッド細胞 (デンドライト,ソマ,またはアクソン初期セグメント) の神経内シナプス形成は,シナプス分子のサブタイプ特異的な発現によって決定される.
- 異なる分子プログラムは,回路形成中に異なるインターニューロンクラスで活性化します.
結論:
- 初期の発達期に確立された細胞特有の分子プログラムは,皮質内ニューロンの正確な接続パターンの根底にある.
- これらのプログラムを理解することは 阻害回路の組み立てと機能を解読する鍵です
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