星 は 宇宙 で は あり ませ ん.アストロ サイト は 環境 の 信号 に 反応 し ます
1Department of Experimental Neuroimmunology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Cell
|January 26, 2019
まとめ
研究者らは,除草剤のリヌロンが,展開されたタンパク質反応経路を標的として, 炎症反応を活性化することを発見しました. このアストロサイトの活性化は,中枢神経系 (CNS) の炎症的損傷を悪化させる.
科学分野:
- 神経科学
- 毒理学について
- 分子生物学
背景:
- アストロサイトは中枢神経系 (CNS) のホメオスタシスと炎症に重要な役割を果たします.
- 環境要因は,アストロサイトの機能に影響し,神経学的障害に寄与する.
研究 の 目的:
- in vivoスクリーニングを使用して,アストロサイト転写プログラムを調節する環境エージェントを識別する.
- 特定の薬物がアストロサイトの反応性と中枢神経の炎症に影響を与えるメカニズムを解明する.
主な方法:
- アストロサイトに影響を与える環境物質を特定するためにゼブラフィッシュの幼虫の体内スクリーニング.
- 展開タンパク質応答 (UPR) 経路の分析
- 反応性アストロサイトにおける炎症性遺伝子発現の評価
- 中枢神経系の組織損傷の評価
主要な成果:
- ウィーラー社 アストロサイトの遺伝子発現を直接変化させる 環境要因を特定した.
- リンロン除草剤はUPR経路を利用することが判明した.
- リヌロンは 反応性のあるアストロサイトで 炎症を誘発するプログラムです
- このリヌーロン誘発のアストロサイト反応は,中枢神経系の炎症性組織損傷を強めた.
結論:
- アストロサイトの機能を 直接再プログラムできます
- リヌロンのメカニズムはUPR経路を巻き込み,有害な炎症性アストロサイト活性化につながる.
- 環境毒素に対するアストロサイトの反応をターゲットにすることは,中枢神経の炎症性疾患に対する潜在的な治療戦略です.
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