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Updated: Jan 30, 2026

Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases
22:00

Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases

Published on: November 21, 2010

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抗結核薬の標的である膜トランスポーターMmpL3の結晶構造

Bing Zhang1, Jun Li2, Xiaolin Yang1

  • 1Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China; University of Chinese Academy of Sciences, Beijing, 100101, China.

Cell
|January 26, 2019
PubMed
まとめ

新しい研究により,Mycobacterium tuberculosis membrane protein Large 3 (MmpL3) の結晶構造と,その結核薬候補との複合体が明らかになりました. この構造的な洞察は,MmpL3を標的とする新しい結核治療の開発に不可欠です.

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