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関連する概念動画

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Cardiopulmonary Resuscitation I: Adult01:21

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Cardiopulmonary resuscitation, or CPR, is a life-saving emergency procedure performed when a person's heart has stopped beating or they are no longer breathing. The foundation of CPR is Basic Life Support (BLS), which focuses on the early recognition of cardiac arrest, the immediate start of high-quality chest compressions, and the timely use of an automated external defibrillator (AED).Assessing Responsiveness and Checking the Carotid PulseWhen approaching an unresponsive person, first ensure...
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Relationship with Other Adult Family Members and Siblings01:29

Relationship with Other Adult Family Members and Siblings

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Other adult family members and siblings play a crucial role in shaping children’s social and emotional development. While parents or primary caregivers are often the central figures in early attachment and socialization, other adults in a child’s life, such as grandparents, aunts, and uncles, can significantly influence developmental outcomes. These influences depend on each adult’s personality and may help compensate when a primary caregiver is emotionally distant or...
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Revisionist Views of Adolescent and Adult Cognition01:24

Revisionist Views of Adolescent and Adult Cognition

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A revisionist approach to Jean Piaget's theory of cognitive development has brought new insights that challenge and reinterpret his established ideas. Piaget proposed that the formal operational stage, emerging in adolescence, represents the culmination of cognitive maturity. During this stage, individuals are said to develop abstract thinking, engage in systematic problem-solving, and show a form of egocentrism, believing others are as preoccupied with their behavior as they are...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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成人における

Roland D Thijs1, Rainer Surges2, Terence J O'Brien3

  • 1Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands; Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands; NIHR University College London Hospitals Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, UK.

Lancet (London, England)
|January 29, 2019
PubMed
まとめ
この要約は機械生成です。

エピレプシは,何百万人にも及ぶ一般的な脳疾患で,複雑な遺伝的障害としてますます理解されています. ゲノム学と診断学の進歩は より良い治療法と 治療の可能性を希望しています

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Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
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Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
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科学分野:

  • 神経学
  • 遺伝学
  • エピレプト学

背景:

  • 乳幼児と高齢者の間でピークを記録しています 乳幼児と高齢者の間でピークを記録しています
  • ゲノムの進歩により の複雑な遺伝的基盤が明らかになり 視野は単一の原因から 多因性状態へと変化しました
  • 発作やの種類について 新しい分類が生まれています

研究 の 目的:

  • エピレプシーに関する現在の理解を概説する.
  • 診断,治療,将来の治療戦略の最近の進歩を強調する.
  • 進化するパラダイムを強調する 複雑な遺伝的障害として

主な方法:

  • エピレプシーの遺伝学,診断,治療に関する最新の科学文献のレビュー.
  • ゲノム技術,脳イメージング,神経調節の進歩の分析
  • 臨床履歴,補助的調査,併発症の検討

主要な成果:

  • は遺伝的傾向が強い 複雑な症状であり 単一の存在ではありません
  • 抗発作薬は多くの患者で発作を制御しますが,すべてではありません.そして長期的な予後を変化させません.
  • 薬剤耐性焦点性では,手術が発作を回避する最良の機会ですが,未充分に利用されています.

結論:

  • エピレプシーの発症,表遺伝学,および薬学遺伝学に関する理解が向上し,病気を修正する治療法や治癒方法への希望を助長しています.
  • 発作検知装置や 応答性神経刺激のような 新しい技術は 将来の治療の機会を提供します
  • 遺伝学,診断,パーソナライズされた治療を統合した 総合的なアプローチは の管理に不可欠です