オックスアル二酸化物とテルト-ブト酸化物:Cu触媒結合反応によるアルキルアリルエーテルへの実用的なアクセスを可能にする2種類のリガンド
Journal of the American Chemical Society
|January 29, 2019
まとめ
新しい方法は,銅の触媒と特殊なリガンドを使用してアルキルアリルエーテルを効率的に準備します. この堅固なプロトコルは,難しい二次アルコールとアリル塩化物を含む様々な基板に有効です.
科学分野:
- 有機化学
- カタリシス
- 合成方法論
背景:
- アルキルアリルエーターは,医薬品や材料における重要な構造モチーフである.
- 合成のための効率的で一般的な方法の開発は,有機化学の重要な課題です.
研究 の 目的:
- アルキルアリルエーテルを合成するための堅牢で実用的なプロトコルを開発する.
- 銅触媒アルコキシル化反応における新型リガンドの使用を調査する.
主な方法:
- 2種類のリガンドを用いた (ヘテロ) アリルハライドの銅触媒アルコキシル化.
- アリル塩化物とブロミドのリガンドとしてオサール二酸化物を使用する.
- アリルイオジドのリガンドとしてテルト・ブトオキシドを使用する.
主要な成果:
- このプロトコルは,様々なコップリングパートナーに対応する幅広い基板の範囲を示しています.
- 挑戦的な二次アルコールと (ヘテロ) アリル塩化物のアルコキシル化が成功しました.
- 炭水化物誘導体からの炭水化物-アリルエーサーの効率的な合成 (29-98%).
結論:
- アルキルアリルエーテル合成のための多用途かつ実用的な銅触媒法が確立されています.
- 開発されたプロトコルは,複雑な炭水化物誘導体を含む多様なアリルエーテル構造にアクセスするための強力なツールを提供します.
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