冠動脈疾患の患者におけるキニジン反応性多形心房短縮症
Sami Viskin1, Ehud Chorin1, Dana Viskin1
1Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Israel (S.V., E.C., D.V., A. Hochstadt, A. Halkin, O.T-B., O.H., B.B., R.R.).
Circulation
|January 31, 2019
まとめ
キニジンは,他の薬が効かない場合,冠動脈疾患の患者における多形性心室低血圧 (VT) を効果的に治療します. このキニジン療法により,静脈梗塞の再発を予防し,不律性ストームを経験した患者の生存率を改善します.
科学分野:
- 心臓病科
- 電気生理学
- 薬理学について
背景:
- QT延長なしの多形心室性短心症 (VT) は,非構造性心疾患および急性心筋梗塞で知られている.
- 急性不血症のない冠動脈疾患 (CAD) でその発生はあまり理解されていません.
研究 の 目的:
- 冠動脈疾患の患者における多形動脈炎を調査する.
- この特定の患者の治療戦略と結果を評価する.
主な方法:
- ポリモルフィックVTを患った43人の患者で,心筋梗塞または再血管化後の遡及的研究.
- 静脈動脈症のトリガー,不律性嵐の発生,キニジンとアミオダロンを含む抗不律性治療に対する反応の分析.
主要な成果:
- 多形静脈動脈事件は,短結合エクストラシストロによって引き起こされた.
- 53% の患者で不律性嵐が発生し,従来の治療には耐性だったが,キニジンに反応した.
- キニジン治療は,長期にわたる再発はなく,すべての治療患者で生存をもたらしました.
結論:
- キニジンは,他の抗リズム薬が効かない場合,重度の多形静脈動脈症および不律性嵐の治療に有効です.
- キニジンの治療は,この集団における治療結果を大幅に改善し,再発を予防します.
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