デング熱
Annelies Wilder-Smith1, Eng-Eong Ooi2, Olaf Horstick3
1London School of Hygiene & Tropical Medicine, London, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany.
Lancet (London, England)
|January 31, 2019
まとめ
死亡率が低いにもかかわらず,重度のデング熱は健康に重大な負担を及ぼします. 研究は診断,治療,ワクチンを進めているが,重篤な病気を予測し,ワクチンの有効性を理解する上で課題が残っている.
科学分野:
- 医療用昆虫学
- 感染症
- ワクチン学
背景:
- 深刻なデング熱は,流行地域における経済と保健サービスの負担を大きくします.
- デング熱の治療法の開発は 病原性を理解する進歩にもかかわらず遅れています
- 抗体依存増強はデング熱の重要な病原性モデルであり,最近では体内で検証されています.
研究 の 目的:
- デング熱の管理,診断,予防の現状を見直す.
- 治療,診断,ワクチンの進行中の研究を強調する.
- 重度のデング熱の予測と介入戦略の改善の必要性を強調する.
主な方法:
- サポートケアと水分補給を含む現在のデング熱管理戦略のレビュー.
- 診療所での核酸増強検査などの新興診断技術の検討
- ワクチン開発の検討,血清状態と保護の相関性の役割を含む.
主要な成果:
- 現在の管理は 血管の漏れを観察し,水分補給を頼りにしています
- 新しい診断ツールは,より高い精度とマルチプレキシング能力を目指しています.
- バイオマーカーの研究は重度のデング熱を予測しようとしています.ワクチンの有効性は血清状態に依存しています.
結論:
- 効果的なデング熱治療法と 深刻な病気の予測のための信頼できるバイオマーカーが 緊急に必要とされています
- ワクチンの保護と病気の強化の相関関係を理解することは極めて重要です.
- 感染媒介者制御とワクチン接種戦略を統合するには,さらなる研究と評価が必要です.
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