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PKG1 改変された TSC2 は,mTORC1 の活動を調節し,有害な心臓ストレスに対抗する

Mark J Ranek1, Kristen M Kokkonen-Simon1, Anna Chen1

  • 1Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Nature
|February 1, 2019
PubMed
まとめ

特定のセリン部位でのチューベリン (TSC2) のリン酸化は,心臓の保護に不可欠なmTORC1の活動を双方向的に制御する. このTSC2酸化は,圧力過負荷に対するタンパク質キナーゼG1 (PKG1) 媒介の心臓保護に不可欠です.

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