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ヒト血清アルブミンからタンパク質に結合した尿性毒素を除去するためのジルコニウムベースの金属有機フレームワーク

  • 0Department of Chemistry and International Institute of Nanotechnology , Northwestern University , 2145 Sheridan Road , Evanston , Illinois 60208 , United States.
Journal of the American Chemical Society +

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2019年2月2日

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Protein Organization 01:13

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Proteins are one of the fundamental building blocks of life that carry out many diverse functions in the cell. Proteins are assembled from amino acids. The sequence of amino acids is known as the primary structure of a protein. Local interactions of individual amino acids cause the linear chain to fold into the secondary structures. Interactions of distant amino acids lead to further folding of the protein—the tertiary structure. The assembly of multiple folded chains (subunits)...

Protein Organization 01:24

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....

Metal-Ligand Bonds 02:51

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...

Alkali Metals 03:06

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Group 1 elements are soft and shiny metallic solids. They are malleable, ductile, and good conductors of heat and electricity. The melting points of the alkali metals are unusually low for metals and decrease going down the group, while the density increases going down the group with the exception of potassium (Table 1).
Table 1: Properties of the alkali metals



Element
Electron Configuration
Atomic Radius (pm)
IE1 (kJ/mol)
Melting Point (°C)
Density at 25 °C...

Types of Toxins 01:36

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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...

Bonding in Metals 02:32

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Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”. 

Electron Sea Model

Most metal atoms do not possess enough valence electrons to enter into an ionic or covalent bonding. However, the valence electrons in metal atoms are loosely held due to their low electronegativity or attraction with the nucleus. The ionization energy of metal atoms (energy required to...