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Assessing Protein Interactions in Live-Cells with FRET-Sensitized Emission
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Published on: April 22, 2021

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遺伝子コード拡張技術に基づくFRETシステムを使用して,単一の生細胞におけるタンパク質相互作用の分析

Seong-Hyun Park1, Wooseok Ko2, Hyun Soo Lee2

  • 1Center for Biofunctional Molecules, Department of Chemistry , Yonsei University , Seoul 03722 , Republic of Korea.

Journal of the American Chemical Society
|February 2, 2019
PubMed
まとめ

熱ショックタンパク質70 (Hsp70) はバックスと結合してアポトーシスを抑制する. 新しいFRET方法は,アポトーシスを誘発する物質が,このHsp70-Bax相互作用をどのように妨げるかを明らかにし,細胞死亡の調節に関する洞察を提供します.

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