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Updated: Jan 30, 2026

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タンパク質対タンパク質相互作用安定剤の発見のための部位指向の断片ベースのスクリーニング

Eline Sijbesma1, Kenneth K Hallenbeck2, Seppe Leysen1

  • 1Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS) , Eindhoven University of Technology , 5600 MB Eindhoven , The Netherlands.

Journal of the American Chemical Society
|February 2, 2019
PubMed
まとめ

研究者達は,タンパク質とタンパク質の相互作用 (PPI) を安定させる小さな分子を発見するために,新しい結合方法を開発しました. この技術は乳がんにおいて重要な14-3-3σとエストロゲン受容体αの相互作用の安定剤を成功裏に特定した.

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