癌細胞におけるミオシンIIの地域活性化は,免疫微環境との分泌クロスチャットを通じて腫瘍の進行を促す
Mirella Georgouli1, Cecilia Herraiz1, Eva Crosas-Molist2
1Randall Centre for Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK.
Cell
|February 5, 2019
まとめ
癌細胞におけるROCK- ミオシンIIの活動は,腫瘍の微小環境を再プログラムすることによって,転移を誘導する. このプロセスはマクロファージを募集し,分化し,異常な血管系を支え,腫瘍の成長を促します.
科学分野:
- 細胞生物学
- 癌 研究
- 免疫学
背景:
- ROCK- ミオシンIIは,転移中の癌細胞の高速で丸いアミーボイドの移動に不可欠です.
- ミオシンII活性度の高いアモエボ型メラノーマ細胞は,腫瘍の侵襲前面,マクロファージと血管の近くで見つかります.
研究 の 目的:
- ガン細胞の移動におけるROCK-ミオシンIIの作用とその腫瘍の微小環境への影響を調査する.
- 癌細胞のミオシンIIダイナミクスが免疫細胞と血管系にどのように影響するか理解する.
主な方法:
- メラノーマのバイオプシの分析
- 癌細胞の分泌体のプロテオミック分析
- ミオシンIIの活性とその影響を研究するために,様々な腫瘍モデルを使用した.
主要な成果:
- アミーボイドがん細胞におけるROCK- ミオシンIIの活動は,単細胞を募集し,腫瘍促進マクロファージへの分化を促進する免疫調節分泌体を制御する.
- 腫瘍細胞とマクロファージの両方が異常な血管系を維持し,腫瘍の進行を促進します.
- ROCK- ミオシンIIによるIL- 1α分泌とNF- kBの活性化により,アミーボイドがん細胞の行動が維持されます.
結論:
- 腫瘍細胞における高ミオシンII活動は 腫瘍の成長を支えるために 生まれながらの免疫マイクロ環境を再プログラムします
- 癌細胞におけるミオシンIIのダイナミクスは,分泌因子を介して骨髄機能の制御に予期せぬ役割を果たします.
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