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リンビックニューロンは性的に素朴な男性における性認識と社会的行動に形を与える
Daniel W Bayless1, Taehong Yang1, Matthew M Mason1
1Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Cell
|February 5, 2019
まとめ
オスマウスのストリア・ターミナリス (BNSTpr) のベッド核にあるアロマターゼ発現神経細胞は,他者の性別をコードし,交尾などの社会的行動を導く. これらのニューロンを静止すると 性別認識と交尾の成功が妨げられます
科学分野:
- 神経科学
- 行動生物学
- 内分泌学
背景:
- 性別を区別することは,性的に素朴な動物における 種特有の社会的相互作用にとって極めて重要です.
- 素朴な哺乳類の性認識を制御する中央神経経路はよく理解されていません.
研究 の 目的:
- ネズミの社会的相互作用と性認識におけるストリア・ターミナリスのベッド核 (BNSTpr) の主要な構成要素の役割を調査する.
- アロマターゼを発現する BNSTpr (AB) ニューロンが性別をコードし,社会的行動を調節することに関与しているかどうかを判断する.
主な方法:
- 性的無意識のマウスで,アロマターゼ発現するBNSTpr (AB) ニューロンの活動を研究した.
- フェロモンの好み,交尾行動,社会的反応への影響を評価するためにニューロンの静止と活性化技術を活用した.
主要な成果:
- 男性のABニューロンの活動は他の動物の性別をコードし,その後の交尾行動に影響します.
- 男性のABニューロンを静止させることで 女性のフェロモンの好みと交尾の成功がなくなりました
- 男性のABニューロンの一時的な活性化により 男性と男性の交尾行動が誘発された.
- 女性ABニューロンは,性別認識,交配,または母性攻撃において重要な役割を果たすようには見えなかった.
結論:
- BNSTprのABニューロンは 性別認識と性的に素朴なマウスの社会的行動を制御するのに不可欠です
- これらの発見は 性別認識に基づく 生まれつきの社会的反応に不可欠な 特定の神経回路を強調しています
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