生まれながらのリンパ球細胞による脂質腺の恒常的制御は,共生細菌の均衡を調節する
Tetsuro Kobayashi1, Benjamin Voisin1, Do Young Kim2
1Cutaneous Leukocyte Biology Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA.
Cell
|February 5, 2019
まとめ
皮膚に宿る先天性リンパ球 (ILC) は,脂質腺と相互作用することで,皮膚の障壁と微生物のバランスを調節する. この免疫-表皮のコミュニケーションは 宿主-微生物の共生に不可欠です
科学分野:
- 免疫学
- 微生物学
- 皮膚科
- 微生物群の研究
背景:
- 皮膚の免疫細胞と上皮は 微生物群と共生関係を形成します
- 皮膚の壁で微生物の共生を制御するメカニズムはよく理解されていません.
- 生まれながらのリンパ性細胞 (ILC) は,バリア組織における重要な免疫要素です.
研究 の 目的:
- 皮膚に宿る ILC の空間的組織と機能を調査する.
- 脂質腺と皮膚の共生を調節するILCの役割を解明する.
- 宿主-微生物の共生を制御する 免疫-表皮回路を理解するために
主な方法:
- 皮膚に居住するILCの空間分割分析
- IL-7と胸膜膜リンパポリエチン (TSLP) に対するILC依存性の調査.
- ケモカイン受容体CCR6によるILC局所化の評価
- TNF受容体のリガンド発現とノッチ信号経路の調節の分析
- 脂質腺のサイズとILCの喪失後の脂質の評価
- 微生物コミュニティのプロフィール作成
主要な成果:
- RORγt+ ILCのサブセットは,脂質腺の近くにある毛胞に存在し,その機能を調節する.
- ILCの持続性と局所化は,IL-7,TSLP,CCR6に依存する.
- ILC由来のTNF受容体リガンドは,Notchシグナル伝達を阻害することによって,血清細胞の増殖を制限する.
- ILCの喪失は,脂質腺の増殖,抗菌性脂質の増加,およびグラム陽性細菌群の変化につながる.
結論:
- 皮質由来信号は皮膚に定着するILCを保持する.
- ILCは,皮の障壁の脂質腺調節を通して微生物の共生を調節する.
- この研究は,宿主-微生物共生に不可欠な免疫-上皮回路を強調しています.
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