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Updated: Jan 29, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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設計された非コーディングRNAの小分子阻害剤は,HER2陰性がんをヘルセプチンに敏感にする

Matthew G Costales1, Dominic G Hoch1, Daniel Abegg1

  • 1Department of Chemistry , The Scripps Research Institute , 130 Scripps Way , Jupiter , Florida 33458 , United States.

Journal of the American Chemical Society
|February 7, 2019
PubMed
まとめ

新種の小分子は選択的にmiR- 515を標的にしてスフィンゴシンキナーゼ1 (SK1) とスフィンゴシン1- リン酸 (S1P) のレベルを上昇させ,HER2- がん細胞をHerceptinのような抗HER2療法に敏感にします.

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